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Cara Mencari Background Pada Folder Windows 7 Tanpa Software Reviews. Adobe Flash Player is required to view this feature. If you are using an operating system that does not support Flash, we are working to bring you alternative formats. Original Article Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension Hossein-Ardeschir Ghofrani, M.D., Andrea M.
D'Armini, M.D., Friedrich Grimminger, M.D., Marius M. Hoeper, M.D., Pavel Jansa, M.D., Nick H.
Kim, M.D., Eckhard Mayer, M.D., Gerald Simonneau, M.D., Martin R. Wilkins, M.D., Arno Fritsch, Ph.D., Dieter Neuser, M.D., Gerrit Weimann, M.D., and Chen Wang, M.D., for the CHEST-1 Study Group N Engl J Med 2013; 369:319-329 DOI: 10.1056/NEJMoa1209657.
Methods In this phase 3, multicenter, randomized, double-blind, placebo-controlled study, we randomly assigned 261 patients with inoperable chronic thromboembolic pulmonary hypertension or persistent or recurrent pulmonary hypertension after pulmonary endarterectomy to receive placebo or riociguat. The primary end point was the change from baseline to the end of week 16 in the distance walked in 6 minutes. Secondary end points included changes from baseline in pulmonary vascular resistance, N-terminal pro–brain natriuretic peptide (NT-proBNP) level, World Health Organization (WHO) functional class, time to clinical worsening, Borg dyspnea score, quality-of-life variables, and safety. Results By week 16, the 6-minute walk distance had increased by a mean of 39 m in the riociguat group, as compared with a mean decrease of 6 m in the placebo group (least-squares mean difference, 46 m; 95% confidence interval [CI], 25 to 67; P. Figure 2 Mean Change from Baseline in the 6-Minute Walk Distance.